4-(7-chloro-5,11-dihydro-10H-benzo[4,5]cyclohepta[1,2-b]pyridin-10-ylidene)-1,1-bis((5-methylpyridin-3-yl)methyl)piperidin-1-ium chloride
3,5-Bis(chloromethyl)pyridine
CAS: 41711-38-0
Molecular Formula: C7H7Cl2N
4-(7-chloro-5,11-dihydro-10H-benzo[4,5]cyclohepta[1,2-b]pyridin-10-ylidene)-1,1-bis((5-methylpyridin-3-yl)methyl)piperidin-1-ium chloride - Names and Identifiers
| Name | 3,5-Bis(chloromethyl)pyridine |
| Synonyms | Rupatadine impurity 9 3,5-Bis(chloromethyl)pyridine PYRIDINE,3,5-BIS(CHLOROMETHYL)- Pyridine,3,5-bis(chloromethyl)-(9CI) 4-(7-chloro-5,11-dihydro-10H-benzo[4,5]cyclohepta[1,2-b]pyridin-10-ylidene)-1,1-bis((5-methylpyridin-3-yl)methyl)piperidin-1-ium chloride |
| CAS | 41711-38-0 |
| InChI | InChI=1/C7H7Cl2N/c8-2-6-1-7(3-9)5-10-4-6/h1,4-5H,2-3H2 |
4-(7-chloro-5,11-dihydro-10H-benzo[4,5]cyclohepta[1,2-b]pyridin-10-ylidene)-1,1-bis((5-methylpyridin-3-yl)methyl)piperidin-1-ium chloride - Physico-chemical Properties
| Molecular Formula | C7H7Cl2N |
| Molar Mass | 176.04 |
| Density | 1.275±0.06 g/cm3(Predicted) |
| Melting Point | 86-87 °C(Solv: ligroine (8032-32-4)) |
| Boling Point | 291.9±30.0 °C(Predicted) |
| pKa | 3.68±0.20(Predicted) |
| Storage Condition | 2-8°C |
| Refractive Index | 1.548 |
4-(7-chloro-5,11-dihydro-10H-benzo[4,5]cyclohepta[1,2-b]pyridin-10-ylidene)-1,1-bis((5-methylpyridin-3-yl)methyl)piperidin-1-ium chloride - Introduction
3,5-Bis(chloromethyl)pyridine is an organic compound with the chemical formula C7H6Cl2N. The following is a description of the properties, uses, preparation and safety information of the compound:
Nature:
-Appearance: 3,5-Bis(chloromethyl)pyridine is a colorless to light yellow liquid.
-Solubility: It has good solubility in common organic solvents, such as ethanol, ether and dichloromethane.
-Melting point and boiling point: melting point is -41 ℃, boiling point is 275 ℃.
-Density: It has a density of 1.39g/cm³.
-Stability: It is a stable compound, but avoid contact with strong oxidants.
Use:
- 3,5-Bis(chloromethyl)pyridine can be used as an important intermediate in organic synthesis. It can participate in a variety of organic reactions, such as Suzuki coupling reaction, Heck reaction, etc., for the synthesis of various organic compounds.
-It can also be used as an intermediate for the synthesis of dyes and pigments and certain pesticides.
- 3,5-Bis(chloromethyl)pyridine can also be used in the preparation of polymers, ceramic materials and coatings.
Preparation Method:
- 3,5-Bis(chloromethyl)pyridine can be prepared by reacting pyridine with methyl chloride under appropriate conditions. The reaction is typically carried out under an inert atmosphere and requires the presence of a catalyst.
Safety Information:
- 3,5-Bis(chloromethyl)pyridine is an organic solvent, which is irritating and toxic. Wear appropriate personal protective equipment, such as gloves and goggles, to avoid contact with skin, eyes and clothing.
-It should be kept away from fire and high temperature. In operation and storage should be used in a well-ventilated place, away from the source of fire.
-In case of inhalation or skin contact, seek medical attention immediately.
-With proper use and storage, the risk of 3,5-Bis(chloromethyl)pyridine can be minimized. Please read and follow the relevant safety instructions before use.
Nature:
-Appearance: 3,5-Bis(chloromethyl)pyridine is a colorless to light yellow liquid.
-Solubility: It has good solubility in common organic solvents, such as ethanol, ether and dichloromethane.
-Melting point and boiling point: melting point is -41 ℃, boiling point is 275 ℃.
-Density: It has a density of 1.39g/cm³.
-Stability: It is a stable compound, but avoid contact with strong oxidants.
Use:
- 3,5-Bis(chloromethyl)pyridine can be used as an important intermediate in organic synthesis. It can participate in a variety of organic reactions, such as Suzuki coupling reaction, Heck reaction, etc., for the synthesis of various organic compounds.
-It can also be used as an intermediate for the synthesis of dyes and pigments and certain pesticides.
- 3,5-Bis(chloromethyl)pyridine can also be used in the preparation of polymers, ceramic materials and coatings.
Preparation Method:
- 3,5-Bis(chloromethyl)pyridine can be prepared by reacting pyridine with methyl chloride under appropriate conditions. The reaction is typically carried out under an inert atmosphere and requires the presence of a catalyst.
Safety Information:
- 3,5-Bis(chloromethyl)pyridine is an organic solvent, which is irritating and toxic. Wear appropriate personal protective equipment, such as gloves and goggles, to avoid contact with skin, eyes and clothing.
-It should be kept away from fire and high temperature. In operation and storage should be used in a well-ventilated place, away from the source of fire.
-In case of inhalation or skin contact, seek medical attention immediately.
-With proper use and storage, the risk of 3,5-Bis(chloromethyl)pyridine can be minimized. Please read and follow the relevant safety instructions before use.
Last Update：2024-04-10 22:29:15
![4-(7-chloro-5,11-dihydro-10H-benzo[4,5]cyclohepta[1,2-b]pyridin-10-ylidene)-1,1-bis((5-methylpyridin-3-yl)methyl)piperidin-1-ium chloride](http://res.chembk.com/assets/str/2d/4/41/41711-38-0.png)